A Zika vaccine could have a substantial effect on mitigating and preventing future Zika virus outbreaks. Through a combination of direct protection and indirect reduction of transmissions, virtual elimination is achievable, even with imperfect vaccine efficacy and coverage. The researcher is published in Annals of Internal Medicine.

Mosquito-borne and sexually transmitted Zika virus has become widespread across Central and South America, and the Caribbean. A viable vaccine is expected to be available in the next several years, but a vaccine’s effectiveness in preventing infections depends not only on its efficacy, but also on demographic and fertility patterns, local Zika attack rates, and the proportion of the population still susceptible when it becomes available.

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